A modified ecarin clotting time test monitors the anticoagulant effects of hirudin

Author

Gandhi, Arpita ; Kristol, David ; Spillert, Charles R.

Author_Institution

New Jersey Inst. of Technol., Newark, NJ, USA

fYear

1999

fDate

8-9 Apr 1999

Firstpage

100

Lastpage

101

Abstract

A rapid blood clotting test for monitoring the thrombin inhibiting activity of the drug hirudin is described. This test, a modified ecarin clotting time may enable the monitoring of a patient´s hirudin dosage so that a safe, therapeutic level is achieved. The results show that there was an increase in clotting time with an increased level of hirudin. The data demonstrates a linear correlation between ecalin clotting time prolongation and hirudin content. Each clotting time is significantly prolonged (p<0.01) in comparison to the clotting time at lower concentrations

Keywords

cardiovascular system; coagulation; haemodynamics; patient monitoring; patient treatment; anticoagulant effects; drug dosage monitoring; hirudin; linear correlation; modified ecarin clotting time test; rapid blood clotting test; safe therapeutic level; thrombin inhibiting activity monitoring; Biomedical monitoring; Blood; Coagulation; Drugs; In vitro; Medical tests; Patient monitoring; Pharmaceutical technology; Proteins; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1999. Proceedings of the IEEE 25th Annual Northeast

Conference_Location

West Hartford, CT

Print_ISBN

0-7803-5486-9

Type

conf

DOI

10.1109/NEBC.1999.755782

Filename

755782