Title :
Reduction of logical models of regulatory networks yields insight into dynamical properties
Author :
Chaouiya, Claudine ; Naldi, Aurélien ; Remy, Elisabeth ; Thieffry, Denis
Author_Institution :
Inst. Gulbenkian de Cienc., Oeiras, Portugal
Abstract :
The logical formalism is a convenient framework to qualitatively model regulatory networks for which detailed quantitative information is barely available. In this discrete framework, network behaviours are usually represented by means of state transition graphs. However, as network sizes increase, state transition graphs often become too large to be effectively constructed, let alone analysed.
Keywords :
delays; discrete systems; graph theory; reduced order systems; delay constraint; discrete framework; dynamical properties; logical formalism; logical model reduction; network behaviour; network size; nonterminal strongly connected components; regulatory network; segment-polarity module; state transition graph; transient oscillation; Biological system modeling; Context; Integrated circuit modeling; Oscillators; Regulators; Trajectory; Transient analysis;
Conference_Titel :
Control Applications (CCA), 2010 IEEE International Conference on
Conference_Location :
Yokohama
Print_ISBN :
978-1-4244-5362-7
Electronic_ISBN :
978-1-4244-5363-4
DOI :
10.1109/CCA.2010.5611238