Title :
A new technology for quantifying behavioral activation in the rodent [using Doppler radar]
Author :
Austin, Kevin B. ; Rose, Gregory M.
Author_Institution :
Dept. of Pharmacology, Colorado Univ., Denver, CO, USA
fDate :
30 Oct-2 Nov 1997
Abstract :
Psychoactive pharmaceuticals developed to treat mental disorders are routinely screened for their ability to produce behavioral activation. Despite many drawbacks, photobeam crossings have been the standard measure of behavioral activation in rodents. This paper describes the use of continuous-wave Doppler radar (CWDR) as an alternative to the standard photobeam box. The CWDR waveform is the direct result of the Doppler shift induced by movement in the field of a high-frequency radio emission. Our data demonstrate a significant correlation between standard photobeam crossing data and the time-integrated RMS value of the CWDR signal. However, the CWDR technique was immune to errors evident in the photobeam crossing data. In addition, the CWDR signal may provide more detailed information about stereotypical movements in place which are not apparent from photobeam crossings
Keywords :
CW radar; Doppler radar; behavioural sciences; biological techniques; biomedical measurement; motion measurement; radar applications; zoology; Doppler shift; activity measurement; behavioral activation quantification; continuous-wave Doppler radar; drug screening; high-frequency radio emission field; mental disorders; photobeam crossings; psychoactive pharmaceuticals; rodent; stereotypical movements; time-integrated RMS value; Doppler radar; Doppler shift; Drugs; Frequency; Light sources; Measurement standards; Mental disorders; Pharmaceutical technology; Psychology; Rodents;
Conference_Titel :
Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
Print_ISBN :
0-7803-4262-3
DOI :
10.1109/IEMBS.1997.756808
