Title :
Towards automated nanomanipulation of nano-bio-entities using real-time molecular force feedback information
Author :
Yang, Yongliang ; Dong, Zaili ; Li, Wen J.
Author_Institution :
State Key Lab. of Robot., Chinese Acad. of Sci., Shenyang
Abstract :
Bovine insulin molecular aggregates, a nano-scale bio-entity, has been manipulated using P-NUVO (programmable nanomanipulation using vibration-mode operation AFM) method. This method uses the amplitude of an AFM cantileverpsilas vibration as real-time feedback information to detect the boundary of the nano-entities under manipulation. This amplitude signal changes as a function of the distance between the probe-tip and a nano-entity due to their inter-molecular force interactions. The AFM tippsilas manipulating path could also be planned according to the manipulation task. Different configuration of bio-nano-entities, i.e., sphere and rod configurations were manipulated. Due to the difficulties of the sample preparation process, the real-time feedback information did not work as well as for other nano-entities such as carbon nanotubes.
Keywords :
atomic force microscopy; biocontrol; feedback; intermolecular forces; manipulators; molecular biophysics; nanotechnology; programmable controllers; AFM cantilever vibration; bovine insulin molecular aggregates; intermolecular force interactions; nanobio-entities; programmable nanomanipulation using vibration-mode operation AFM method; real-time molecular force feedback information; Aggregates; Atomic force microscopy; Bovine; Force feedback; Insulin; Mechanical factors; Nanoparticles; Real time systems; Robotics and automation; Vibrations; AFM; Automated nanomanipulation; Bio-nano-manipulation; Nano-robotics; Programmable nanomanipulation;
Conference_Titel :
Information and Automation, 2008. ICIA 2008. International Conference on
Conference_Location :
Changsha
Print_ISBN :
978-1-4244-2183-1
Electronic_ISBN :
978-1-4244-2184-8
DOI :
10.1109/ICINFA.2008.4608238
