Title :
Elastin-like polypeptide-doxorubicin conjugates for cancer therapy
Author :
Dreher, Matthew ; Raucher, Drazen ; Balu, Narayanan ; Colvin, Michael ; Hudeman, S. ; Chilkoti, Ashutosh
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
Thermally responsive elastin-like polypeptides (ELP) were synthesized by recombinant DNA techniques and conjugated to doxorubicin through an acid labile bond. The thermal properties, release of doxorubicin, uptake of ELP, cytotoxicity and cellular localization of ELP-doxorubicin conjugates were investigated in this study.
Keywords :
DNA; biochemistry; biothermics; cancer; cellular transport; patient treatment; polymers; proteins; tumours; 0 to 1 week; 37 C; 42 C; 7 day; acid labile bond; cancer therapy; cellular localization; cytotoxicity; drug delivery; elastin-like polypeptide-doxorubicin conjugates; pH-controlled release; recombinant DNA techniques; thermal properties; thermally responsive polypeptides; thermosensitive polymers; Bonding; Cancer; DNA; Drugs; Hyperthermia; Medical treatment; Neoplasms; Optical buffering; Optical scattering; Plasma temperature;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1136930
