A new understanding of osteocyte process ultrastructure

Author

You, L.D. ; Weinbaum, S. ; Cowin, S.C. ; Schaffler, M.B.

Author_Institution

Dept. of Mech. Eng., Stanford Univ., CA, USA

Volume

1

fYear

2002

fDate

2002

Firstpage

589

Abstract

Bone adapts readily and rapidly to its mechanical loading environment to give rise to a functionally well designed tissue and organ. The "mechanosensor" for bone adaptation is widely believed to be the osteocyte. However, to date we have only a very preliminary knowledge of how these cells function in this regard. A new model was advanced recently which suggest a potential mechanism of mechanotransduction in bone. We then experimentally verified and measured the essential biological elements assumed by this new model using ultrastructural method.

Keywords

biomechanics; bone; cellular biophysics; bone cells; bone mechanical adaptation; drag force; essential biological elements; mechanical loading environment; mechanotransduction; osteocyte process ultrastructure; shear stress; Animals; Bones; Capacitive sensors; Cities and towns; Deformable models; Educational institutions; Electron microscopy; Ethanol; Mechanical engineering; Orthopedic surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1136965

Filename

1136965