Title :
Advanced substrates in sol-gel technology for MALDI mass spectrometry
Author :
Dima, A. ; Carlsson, A. ; Broo, K. ; Arwin, H.
Author_Institution :
Nat. Inst. for R&D in Microtechnology, Bucharest, Romania
Abstract :
Sol-gel SiO2 thin films for matrix-assisted laser desorption/ionization (MALDI) matrices are presented. The layers organically modified with 2,5-dihydroxybenzoic acid (DHB) and α-cyano 4-hydroxy cinnamic acid (CHCA) to generate hybrid sol-gel films. Hydrolysis and condensation reactions from solution were followed with UV/VIS spectrometry, and ellipsometric characterisation is done with reference to standard SiO2 layers. The layers are part of an intelligent-surface design program, this application being aimed at reducing matrix-"background" interference in MALDI spectra. The layers were engineered as industrially integrable, having good aging properties, excellent stability under light, as well as good mechanical properties - homogeneous, crack free.
Keywords :
chemical reactions; ellipsometry; insulating thin films; liquid phase deposited coatings; mass spectroscopic chemical analysis; organic-inorganic hybrid materials; silicon compounds; sol-gel processing; substrates; ultraviolet spectroscopy; visible spectroscopy; α-cyano 4-hydroxy cinnamic acid; 2,5-dihydroxybenzoic acid; MALDI mass spectrometry; MALDI spectra; SiO2; UV/VIS spectrometry; condensation; ellipsometric characterisation; hybrid sol-gel films; hydrolysis; intelligent-surface design program; matrix-assisted laser desorption/ionization; matrix-background interference; sol-gel technology; sol-gel thin films; substrates; Active matrix organic light emitting diodes; Chemical analysis; Chemical technology; Interference; Laser stability; Mass spectroscopy; Signal analysis; Solvents; Stability analysis; Substrates;
Conference_Titel :
Semiconductor Conference, 2004. CAS 2004 Proceedings. 2004 International
Print_ISBN :
0-7803-8499-7
DOI :
10.1109/SMICND.2004.1402809
