Title :
Instrumentation enabling the chronic assessment of neural activity: A novel case study of hibernation in Ursus americanus
Author :
Laske, T.G. ; Garshelis, D.L. ; Iaizzo, P.A. ; Carlson, D. ; Jensen, R. ; Stanslaski, S. ; Weiss, S. ; Afshar, P. ; Cong, P. ; Denison, T.
Author_Institution :
Medtronic, USA
Abstract :
We present a fully implantable, chronic system for untethered neuroscience research in freely behaving animals. The system infrastructure provides an experimental toolkit for recording electrical signals and activating neural tissues via a neurostimulator. This system provides the ability to investigate the dynamic behavior of neural circuits without the limitations of typical acute laboratory environments, tethered links, or the confounds of anesthesia that may undermine data interpretation. The engineering behind this device is briefly discussed with an emphasis on system considerations for chronic use. We describe here an implant in a black bear, Ursus americanus, to demonstrate system capabilities and provide a report of brain activity during bear hibernation.
Keywords :
bioelectric phenomena; biological tissues; brain; data recording; medical signal processing; networks (circuits); neurophysiology; prosthetics; Ursus americanus; acute laboratory environments; anesthesia; chronic assessment; data interpretation; electrical signal recording; hibernation; implantable system; neural activity; neural circuits; neural tissues; neuroscience; neurostimulator; Animals; Instruments; Protocols; Sensors; Surgery; Telemetry; Time domain analysis;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-1469-6
DOI :
10.1109/BioCAS.2011.6107737
