CMOS low current measurement system for nanopore sensing applications

Author

Goldstein, Brian ; Kim, Dongsoo ; Magoch, Malgorzata ; Astier, Yann ; Culurciello, Eugenio

Author_Institution

Dept. of Electr. Eng., Yale Univ., New Haven, CT, USA

fYear

2011

fDate

10-12 Nov. 2011

Firstpage

265

Lastpage

268

Abstract

We present a 16 channel micro-chip implementation of a low current measurement system for use in automated nanopore sensing applications using capacitive feedback. We successfully used our device to perform voltage-clamping and current measurement across specially designed nanopores for low voltage sensing to detect the presence of nanoparticles. Nanoparticle events in the pore can be seen as transient changes in current from the standing current. We demonstrate our system by detecting events from 2 ms to 50 ms with a 250 pA to 350 pA change from the baseline current.

Keywords

CMOS integrated circuits; biomedical electronics; biomedical measurement; biosensors; electric current measurement; lab-on-a-chip; nanomedicine; nanoparticles; nanosensors; 16 channel microchip implementation; CMOS low current measurement system; baseline current; capacitive feedback; current 250 pA to 350 pA; current measurement; nanoparticles; nanopore sensing application; voltage sensing; voltage-clamping measurement; Biomedical measurements; Current measurement; Etching; Nanobioscience; Nanoparticles; Noise; Voltage measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE

Conference_Location

San Diego, CA

Print_ISBN

978-1-4577-1469-6

Type

conf

DOI

10.1109/BioCAS.2011.6107778

Filename

6107778