Title :
Analog transistor models of bacterial genetic circuits
Author :
Daniel, Ramiz ; Woo, Sung Sik ; Turicchia, Lorenzo ; Sarpeshkar, Rahul
Author_Institution :
Electr. Eng. & Comput. Sci., Massachusetts Inst. of Technol., Cambridge, MA, USA
Abstract :
We show that compact analog current-mode circuits are effective at quantitatively modeling the behavior of genetic circuits. We present experimental biological data from genetic activator (PBAD) and repressor (PlacO) promoter circuits in E. coli. Simple subthreshold cascaded-differential-pair transistor circuits have input-output characteristics that quantitatively represent this data. Such foundational analog circuits can provide efficient conceptual, modeling, and simulation tools for the design and analysis of circuits in synthetic and systems biology.
Keywords :
microorganisms; transistor circuits; E. coli; PBAD promoter circuit; PlacO promoter circuit; analog transistor model; bacterial genetic circuits; compact analog current mode circuits; genetic activator; repressor; subthreshold cascaded differential pair transistor circuits; Biological system modeling; Fluorescence; Genetics; Integrated circuit modeling; Mathematical model; Proteins; Transistors;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-1469-6
DOI :
10.1109/BioCAS.2011.6107795
