DocumentCode
2716776
Title
Analog transistor models of bacterial genetic circuits
Author
Daniel, Ramiz ; Woo, Sung Sik ; Turicchia, Lorenzo ; Sarpeshkar, Rahul
Author_Institution
Electr. Eng. & Comput. Sci., Massachusetts Inst. of Technol., Cambridge, MA, USA
fYear
2011
fDate
10-12 Nov. 2011
Firstpage
333
Lastpage
336
Abstract
We show that compact analog current-mode circuits are effective at quantitatively modeling the behavior of genetic circuits. We present experimental biological data from genetic activator (PBAD) and repressor (PlacO) promoter circuits in E. coli. Simple subthreshold cascaded-differential-pair transistor circuits have input-output characteristics that quantitatively represent this data. Such foundational analog circuits can provide efficient conceptual, modeling, and simulation tools for the design and analysis of circuits in synthetic and systems biology.
Keywords
microorganisms; transistor circuits; E. coli; PBAD promoter circuit; PlacO promoter circuit; analog transistor model; bacterial genetic circuits; compact analog current mode circuits; genetic activator; repressor; subthreshold cascaded differential pair transistor circuits; Biological system modeling; Fluorescence; Genetics; Integrated circuit modeling; Mathematical model; Proteins; Transistors;
fLanguage
English
Publisher
ieee
Conference_Titel
Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE
Conference_Location
San Diego, CA
Print_ISBN
978-1-4577-1469-6
Type
conf
DOI
10.1109/BioCAS.2011.6107795
Filename
6107795
Link To Document