Title :
An ISFET based chemical Gilbert Cell
Author :
Kalofonou, Melpomeni ; Georgiou, Pantelis ; Toumazou, Christofer
Author_Institution :
Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK
Abstract :
This paper presents an ISFET based chemical Gilbert Cell capable of differential measurement of pH signals during thermocycling reactions. Such a process is important for DNA analysis during PCR, with the capability to be applied in Lab-On-Chip (LOC) topologies. The proposed circuit is capable of measuring the difference between two reaction chambers allowing stable drift reduction. The system has been designed and fabricated in a typical 0.35μm CMOS process, with the resulting topology achieving differential measurement, tunable gain of up to 40dB, temperature stability, with a variation of just 0.7% within the range of 0 to 100°C and a low power consumption of 198nW.
Keywords :
CMOS integrated circuits; DNA; biochemistry; biological techniques; biomolecular electronics; enzymes; integrated circuit design; ion sensitive field effect transistors; lab-on-a-chip; molecular biophysics; pH measurement; CMOS process; DNA analysis; ISFET based chemical Gilbert cell; LOC topology; PCR; differential measurement; lab-on-chip topology; low power consumption; pH signal measurement; size 0.35 mum; temperature 0 degC to 100 degC; temperature stability; thermocycling reactions; Chemical sensors; Chemicals; Passivation; Temperature measurement; Temperature sensors; Threshold voltage; Gilbert Cell; ISFET; Lab-On-Chip; low power; temperature stable; tunable gain;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-1469-6
DOI :
10.1109/BioCAS.2011.6107803
