DocumentCode :
2718073
Title :
Microbial drug target identification using different computational approaches: Specific application to Pseudomonas aeruginosa
Author :
Perumal, Deepak ; Lim, Chu Sing ; Sakharkar, Meena K.
Author_Institution :
Pharmacogenomics Group, Nanyang Technol. Univ., Singapore
fYear :
2008
fDate :
16-18 Dec. 2008
Firstpage :
135
Lastpage :
139
Abstract :
Traditionally, most bacterial drug targets are identified using expensive and time-consuming genetic screens, biochemical tests and cellular assays. In recent times, drug-target identification by in silico methods has emerged causing a phenomenal achievement in the field of drug discovery. This paper focuses on describing how microbial drug target identification can be carried out using bioinformatics. Specifically, it highlights the use of the following methodologies for drug target identification: metabolic dasiachoke pointpsila and dasiaload pointpsila analyses, homology-based analysis of drug target identification, DrugBank database and structure based druggability analysis of PDB structures. More systems analysis methods should be developed for understanding metabolic network in drug discovery process which in turn will generate more in-depth understanding of the mechanism of diseases and thus provide better guidance for drug discovery.
Keywords :
bioinformatics; Pseudomonas aeruginosa; bacterial drug targets; biochemical tests; bioinformatics; cellular assays; microbial drug target identification; Antibiotics; Biochemistry; Bioinformatics; Computer applications; Drugs; Genomics; Immune system; Inductors; Microorganisms; Proteins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Innovations in Information Technology, 2008. IIT 2008. International Conference on
Conference_Location :
Al Ain
Print_ISBN :
978-1-4244-3396-4
Electronic_ISBN :
978-1-4244-3397-1
Type :
conf
DOI :
10.1109/INNOVATIONS.2008.4781728
Filename :
4781728
Link To Document :
بازگشت