Automated Quantitation of Zebrafish Somites in High-Throughput Screens

Author

Lu, Jianfeng ; Liu, Tianming ; Nie, Jingxin ; Ding, Jie ; Zhu, Jinmin ; Yang, Jingyu ; Guo, Lei ; Xia, Weiming ; Wong, Stephen T C

Author_Institution

Dept. of Comput. Sci. & Technol., Nanjing Univ. of Sci. & Technol.

fYear

2006

fDate

38899

Firstpage

1

Lastpage

2

Abstract

With the availability of high-throughput imaging machines and large number of zebrafish embryos, zebrafish is by far one of the most cost-effective vertebrate systems for high-throughput or high-content screens. With the tremendous amount of images generated from large numbers of zebrafish, computerized image analysis for accurate and efficient data interpretation becomes essential. This paper presents an automated algorithm for quantitation of zebrafish somite in high-throughput screen. Preliminary evaluation results are shown to demonstrate the performance of the algorithm. This algorithm has been integrated into our CBI platform

Keywords

biomedical optical imaging; medical image processing; automated zebrafish somite quantitation; computerized image analysis; cost-effective vertebrate systems; data interpretation; high-throughput imaging machines; high-throughput screens; zebrafish embryos; Bioinformatics; Biomedical imaging; Computer science; Diseases; Drugs; Embryo; Image analysis; In vivo; Inhibitors; Radiology;

fLanguage

English

Publisher

ieee

Conference_Titel

Life Science Systems and Applications Workshop, 2006. IEEE/NLM

Conference_Location

Bethesda, MD

Print_ISBN

1-4244-0277-8

Electronic_ISBN

1-4244-0278-6

Type

conf

DOI

10.1109/LSSA.2006.250389

Filename

4015790