DocumentCode :
2722538
Title :
Static and dynamic cardiac modelling: Initial strides and results towards a quantitatively accurate mechanical heart model
Author :
Constantinides, C. ; Aristokleous, N. ; Johnson, G.A. ; Perperides, D.
Author_Institution :
Lab. of Physiol. & Biomed. Imaging, Univ. of Cyprus, Nicosia, Cyprus
fYear :
2010
fDate :
14-17 April 2010
Firstpage :
496
Lastpage :
499
Abstract :
Magnetic Resonance Imaging (MRI) has exhibited significant potential for quantifying cardiac function and dysfunction in the mouse. Recent advances in high-resolution cardiac MR imaging techniques have contributed to the development of acquisition approaches that allow fast and accurate description of anatomic structures, and accurate surface and finite element (FE) mesh model constructions for study of global mechanical function in normal and transgenic mice. This study presents work in progress for construction of quantitatively accurate three-dimensional (3D) and 4D dynamic surface and FE models of murine left ventricular (LV) muscle in C57BL/6J (n=10) mice. Constructed models are subsequently imported into commercial software packages for the solution of the constitutive equations that characterize mechanical function, including computation of the stress and strain fields. They are further used with solid-free form fabrication processes to construct model-based material renditions of the human and mouse hearts.
Keywords :
biomechanics; biomedical MRI; cardiovascular system; image segmentation; medical image processing; mesh generation; muscle; physiological models; software prototyping; 3-D dynamic surface model; 4-D dynamic surface model; FE mesh model; LV muscle; MRI; cardiac dysfunction; cardiac function; cardiovascular system; dynamic cardiac modelling; finite element mesh model; high-resolution cardiac MR imaging; left ventricular muscle; magnetic resonance imaging; mechanical heart model; model-based material rendition; rapid prototyping; solid-free form fabrication; static cardiac modelling; Capacitive sensors; Equations; Finite element methods; Heart; High-resolution imaging; Magnetic resonance imaging; Mice; Muscles; Software packages; Stress; Magnetic Resonance Imaging; cardiovascular system; finite element methods; image processing; rapid prototyping;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2010 IEEE International Symposium on
Conference_Location :
Rotterdam
ISSN :
1945-7928
Print_ISBN :
978-1-4244-4125-9
Electronic_ISBN :
1945-7928
Type :
conf
DOI :
10.1109/ISBI.2010.5490300
Filename :
5490300
Link To Document :
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