Real-time theoretical compartmental model of blood-brain barrier drug delivery

This study developed upon the Mahar Doan and Boje simulations to create a novel pharmacokinetic/pharmacodynamic real-time compartmental model in Simulink. The model allowed for varying combinations of oral and intravenous drug dosing under steady and nonsteady-state endogenous transport inhibition methods. A joint pharmacodynamic model simulated an extracellular receptor binding process and an intracellular enzymatic process as drug effect sites. Initial simulations were compared with the Mahar Doan and Boje data. Further simulation demonstrated the freedom and broadened understanding of drug kinetics and dynamics the implemented real-time model provided.