DocumentCode
272629
Title
Influence of the architecture on the molecular mobility of synthetic fragments inspired from human tropoelastin
Author
Samouillan, ValeÌrie ; Dandurand, Jany ; CausseÌ, Nicolas ; Lacabanne, Colette ; Bochicchio, Brigida ; Pepe, Antonietta
Author_Institution
Polymer Phys., Paul Sabatier Univ., Toulouse, France
Volume
22
Issue
3
fYear
2015
fDate
Jun-15
Firstpage
1427
Lastpage
1433
Abstract
This work deals with the vibrational, thermal and dielectric characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin. This peptide was shown to form amyloid-like fibers implied in neurodegenerative pathologies. The comparison between the linear peptides and the associated amyloidlike fibers evidences the strong influence of the secondary structures on the physical structure and chain dynamics of these polypeptides.
Keywords
biothermics; molecular biophysics; molecular configurations; polymers; amyloid-like fibers; dielectric characterization; human tropoelastin; human tropoelastin proteolysis; linear peptides; molecular mobility; neurodegenerative pathologies; polypeptide chain dynamics; polypeptide physical structure; secondary structures; synthetic peptide; thermal characterization; vibrational characterization; Dielectrics; Isothermal processes; Optical fiber networks; Optical fiber theory; Peptides; Spectroscopy; Temperature distribution; biological materials; calorimetry; infrared spectroscopy; permittivity measurements; thermally stimulated currents;
fLanguage
English
Journal_Title
Dielectrics and Electrical Insulation, IEEE Transactions on
Publisher
ieee
ISSN
1070-9878
Type
jour
DOI
10.1109/TDEI.2015.7116333
Filename
7116333
Link To Document