Title :
In-memory technology enables interactive drug response analysis
Author :
Schapranow, Matthieu-P ; Klinghammer, Konrad ; Fähnrich, Cindy ; Plattner, Hasso
Author_Institution :
Enterprise Platform & Integration Concepts, Hasso Plattner Inst., Potsdam, Germany
Abstract :
Latest medical diagnostics generate increasing amounts of big medical data. Specific software tools optimized for the use by healthcare experts and researchers as well as systematic processes for data processing and analysis in clinical and research environments are still missing. Our work focuses on the integration of high-throughput next-generation sequencing data and its systematic processing and its instantaneous analysis to use them in the course of precision medicine. We share our research results on designing a generic research process for drug response analysis including specific software tools built on top of our distributed in-memory computing platform for processing of big medical data. Furthermore, we present our technical foundations as well as process aspects of integrating and combining heterogeneous data sources, such as genome, patient, and experimental data.
Keywords :
Big Data; data analysis; database management systems; drugs; genomics; health care; medical information systems; optimisation; patient diagnosis; sequences; big medical data generation; big medical data processing; clinical environment; distributed in-memory computing platform; experimental data; generic research process design; genome data; healthcare expert software tool; healthcare researcher software tool; heterogeneous data source combination; heterogeneous data source integration; high-throughput next-generation sequencing data integration; in-memory technology; instantaneous analysis; interactive drug response analysis; medical diagnostics; patient data; precision medicine; research environment; software tool optimization; systematic data analysis; systematic data processing; Bioinformatics; Data analysis; Databases; Drugs; Genomics; Tumors; Drug Response Analysis; E-Health; Genome Data Analysis; In-Memory Database Technology; Next-Generation Sequencing; Process Integration;
Conference_Titel :
e-Health Networking, Applications and Services (Healthcom), 2014 IEEE 16th International Conference on
Conference_Location :
Natal
DOI :
10.1109/HealthCom.2014.7001879