Study on the stability of nanodrugs using particulate growth technique

It is known that the particulate size distribution is one of the most important characteristics for the evaluation of the stability of colloidal systems. Therefore, the particulate size parameters and polydispersity index (PDI) were evaluated immediately after the production of the nanosuspensions by wet nanomilling, and also at 1 week to 6 weeks of storage (when feasible) under three different temperatures (4°C, 25°C and 40°C) to monitor physical stability (particle growth). The systems remained in their colloidal particulate size range (<;1 um) for nanoparticulate drugs were observed. The PDIs of nanoparticulate drugs were obtained at below 1.0.