Multifunctional neuroprobes with integrated chemical and electrical neural interfaces

This paper summarizes ongoing efforts in our laboratory to develop next-generation implantable neuroprobe systems that have closely integrated chemical and electrical neural interfaces. The MEMS-based neuroprobe consists of a silicon or polymer substrate having multiple metal sites for electrical recording and/or stimulation and one or more microchannels for fluid delivery. A chronoamperometric chemical sensor is achieved by selectively coating metal sites with an ion selective membrane. This multifunctional neuroprobe system provides a novel technology for establishing chronic and controllable chemical and electrical interfaces to targeted areas of the brain and spinal cord.