Title :
The alternation of cellular viscoelasticity and cellular response in endothelial cell under hyperglycemia
Author :
Jang, Hyunyoung ; Targovnik, Jerome ; Massia, Stephen
Author_Institution :
Dept. of Bioeng., Arizona State Univ., Tucson, AZ, USA
Abstract :
To investigate the effect of hyperglycemia on cellular viscoelastic properties in bovine endothelial cells (BECs), rheology was employed. We found that the viscoelastic properties of BECs were altered under high glucose environment. Also high glucose suppressed the formation of actin filament and focal contacts.
Keywords :
biomechanics; blood vessels; cellular biophysics; diseases; haemorheology; molecular biophysics; proteins; sugar; viscoelasticity; actin filament; bovine endothelial cells; cellular response; cellular viscoelasticity; endothelial cell; glucose environment; hyperglycemia; rheology; Atherosclerosis; Biomedical engineering; Bovine; Elasticity; Frequency; Mechanical factors; Pathogens; Rheology; Sugar; Viscosity;
Conference_Titel :
Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE
Print_ISBN :
0-7803-7789-3
DOI :
10.1109/IEMBS.2003.1281011
