Model based analysis of cerebrovascular oscillation using the system Circle of Willis

Low frequency fluctuation (oscillation) can be observed in the cerebral blood flow under the following condition. The physiological phenomenon´s frequency range is about 4-12 cpm (0; 06 - 0; 2 Hz). Independent from location, in both of the hemispheres the observed phenomenon shows high level of correlation, although previously its local enhancement was proved. The concrete physiological mechanism, controlling this oscillation has not been identified. One potential natural reason for the synchronous appearance of the oscillation is the structure of arteries, on the base of the brain, the so called Circle of Willis (CoW). In order to analyze the potential causes, physiological phenomenon´s controlling mechanism, the CoW model has been modified in order to reflect the experimental setup. In this paper we demonstrate the evaluation of the measurement, the modified model and present the simulation results.