Title :
Poster: In silico hypotheses of the Aβ42 peptide aggregation process in Alzheimer´s disease
Author :
Ghosh, Preetam ; Datta, Bhaswati ; Rangachari, Vijayaraghavan
Author_Institution :
Sch. of Comput., Univ. of Southern Mississippi, Hattiesburg, MS, USA
Abstract :
In Alzheimer´s disease (AD), the aggregates of amyloid-β (Aβ) peptide form large fibrillar deposits and are believed to be the cause for cognitive decline. Hence, the nucleation dependent Aβ aggregation process has been subject to intense investigation for biophysical understanding. Here, we present a molecular-level simulation model to understand and predict the dynamics of this process supported by in vitro biophysical analyses data.
Keywords :
aggregation; cognition; diseases; molecular biophysics; nucleation; physiological models; proteins; Aβ42 peptide aggregation; Alzheimer disease; amyloid-β peptide; cognitive decline; in silico hypotheses; in vitro biophysical analyses data; molecular level simulation model; nucleation; Biological system modeling; Biomedical monitoring; Data models; Kinetic theory; Peptides; Proteins;
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-61284-851-8
DOI :
10.1109/ICCABS.2011.5729897
