DocumentCode
2737184
Title
Poster: In silico hypotheses of the Aβ42 peptide aggregation process in Alzheimer´s disease
Author
Ghosh, Preetam ; Datta, Bhaswati ; Rangachari, Vijayaraghavan
Author_Institution
Sch. of Comput., Univ. of Southern Mississippi, Hattiesburg, MS, USA
fYear
2011
fDate
3-5 Feb. 2011
Firstpage
244
Lastpage
244
Abstract
In Alzheimer´s disease (AD), the aggregates of amyloid-β (Aβ) peptide form large fibrillar deposits and are believed to be the cause for cognitive decline. Hence, the nucleation dependent Aβ aggregation process has been subject to intense investigation for biophysical understanding. Here, we present a molecular-level simulation model to understand and predict the dynamics of this process supported by in vitro biophysical analyses data.
Keywords
aggregation; cognition; diseases; molecular biophysics; nucleation; physiological models; proteins; Aβ42 peptide aggregation; Alzheimer disease; amyloid-β peptide; cognitive decline; in silico hypotheses; in vitro biophysical analyses data; molecular level simulation model; nucleation; Biological system modeling; Biomedical monitoring; Data models; Kinetic theory; Peptides; Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on
Conference_Location
Orlando, FL
Print_ISBN
978-1-61284-851-8
Type
conf
DOI
10.1109/ICCABS.2011.5729897
Filename
5729897
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