Poster: HORIBALFRE: Higher Order Residue Interactions Based ALgorithm for Fold REcognition

In an attempt to enhance the potential based fold - recognition methods of remote homologs, we propose a new approach “Higher Order Residue Interaction Based ALgorithm for Fold REcognition (HORIBALFRE)”, where we incorporated the potential contributions not just from one-body and two-body terms, but from three body (triplet interactions) and four-body (quadruple interaction) interactions, to implement a new fold recognition method. Core of HORIBALFRE includes the potentials generated from a structure library derived from CAMPASS database of structure based sequence alignment. Currently, the algorithm is applied to the Fischer´s dataset. Our preliminary result indicates that inclusion of higher order residue interaction (quadruple) potentials increases the prediction performance.