Title :
Invited: A novel perspective in algorithmic combinatorial methods for phasing populations in a coalescent model
Author :
Bonizzoni, Paola
Author_Institution :
Dipt. di Inf. Sist. e Comun., Univ. di Milano-Bicocca, Milan, Italy
Abstract :
The goal of the present talk is to discuss some recent perspectives and challenges in facing the emerging computational problems related to phasing on datasets produced by new-generation technologies.It also discusess the need to develop new models, as well as some relevant concepts related to new datasets, such as Identity by Descent (IBD) which happens when two haplotypes are the same because they carry copies of the same original haplotype transmitted by a common ancestor and Identity by State (IBS) which happens when two haplotypes are the same.
Keywords :
bioinformatics; combinatorial mathematics; genetics; Identity by Descent; Identity by State; algorithmic combinatorial methods; coalescent model; haplotypes; phasing; Bioinformatics; Computational modeling; Data models; Genetics; Materials; Phylogeny; Throughput;
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2011 IEEE 1st International Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-61284-851-8
DOI :
10.1109/ICCABS.2011.5729936