Stokesian Dynamics Simulation of Nano-magnets under External Magnetic Field

Targeting technique is the key of drug delivery system (DDS) whose ultimate aim is enhancement of efficiency of medication form. The use of magnetic nanoparticles in targeted drug delivery systems is under investigation by several research groups. Therapeutic drug molecules have been immobilized on the surface of magnetic nanoparticles or nanocrystals and directed to a specific target tissue using a magnetic field gradient. In this study, we analyze the motion of a mass of nano-magnets in incompressible fluid at a microscale by stokesian dynamics simulation method. As a result, it is confirmed that every nano-magnet´s magnetic moment turn to the magnetic field direction and the mass of nano-magnets forms chain-like structure along the direction of external magnetic field. Although we come out the strength of magnetic field has not too effect on mass behavior, improvement of the method is required in respect to the magnetic gradient which affects translational motion.