Title :
Opto-fluidic detection system enabling sophisticated point-of-care diagnostics
Author :
Kiesel, Peter ; Beck, Markus ; Martini, Joerg ; Johnson, Noble ; Huck, Malte
Author_Institution :
PARC (Palo Alto Res. Center), Palo Alto, CA, USA
Abstract :
Most biomedical tests are performed at large clinical laboratories because compact, robust, and inexpensive instruments for point-of-care (POC) testing are simply not available. Yet there is a need for POC testing. Optofluidic systems for fluorescence detection of bio-particles offer high performance, but they cannot meet POC specifications. We have demonstrated, prototyped, and benchmarked against commercial systems a new optical detection approach that delivers high signal-to-noise discrimination without complex optics or bulky excitation sources. It therefore enables a truly compact, low-cost, high-performance microfluidic-based instrument that can be used for CD4 diagnostics on whole blood and for other complex biological fluids.
Keywords :
bioMEMS; biomedical measurement; blood; fluorescence; lab-on-a-chip; microfluidics; patient diagnosis; photodiodes; prototypes; BD FACSCount instrument; CD4 diagnostics; HIV infected patient; POC testing; biological fluid; biomedical test; bioparticle detection; fluidic chip; fluorescence; optical transmission; optofluidic detection system; pin photodiode; point-of-care diagnostics; prototype; signal-to-noise discrimination; spatial modulation; whole blood; Blood; Calibration; Fluorescence; Instruments; Pollution measurement; Prototypes; Semiconductor device measurement;
Conference_Titel :
Winter Topicals (WTM), 2011 IEEE
Conference_Location :
Keystone, CO
Print_ISBN :
978-1-4244-8428-7
DOI :
10.1109/PHOTWTM.2011.5730047
