Opto-fluidic detection system enabling sophisticated point-of-care diagnostics

Author

Kiesel, Peter ; Beck, Markus ; Martini, Joerg ; Johnson, Noble ; Huck, Malte

Author_Institution

PARC (Palo Alto Res. Center), Palo Alto, CA, USA

fYear

2011

fDate

10-12 Jan. 2011

Firstpage

63

Lastpage

64

Abstract

Most biomedical tests are performed at large clinical laboratories because compact, robust, and inexpensive instruments for point-of-care (POC) testing are simply not available. Yet there is a need for POC testing. Optofluidic systems for fluorescence detection of bio-particles offer high performance, but they cannot meet POC specifications. We have demonstrated, prototyped, and benchmarked against commercial systems a new optical detection approach that delivers high signal-to-noise discrimination without complex optics or bulky excitation sources. It therefore enables a truly compact, low-cost, high-performance microfluidic-based instrument that can be used for CD4 diagnostics on whole blood and for other complex biological fluids.

Keywords

bioMEMS; biomedical measurement; blood; fluorescence; lab-on-a-chip; microfluidics; patient diagnosis; photodiodes; prototypes; BD FACSCount instrument; CD4 diagnostics; HIV infected patient; POC testing; biological fluid; biomedical test; bioparticle detection; fluidic chip; fluorescence; optical transmission; optofluidic detection system; pin photodiode; point-of-care diagnostics; prototype; signal-to-noise discrimination; spatial modulation; whole blood; Blood; Calibration; Fluorescence; Instruments; Pollution measurement; Prototypes; Semiconductor device measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Winter Topicals (WTM), 2011 IEEE

Conference_Location

Keystone, CO

Print_ISBN

978-1-4244-8428-7

Type

conf

DOI

10.1109/PHOTWTM.2011.5730047

Filename

5730047