Title :
Oxidized LDL as an Effective Anti-Cancer Bio Nanoparticle
Author :
Wang, Pei-Wen ; Chen, Chu-Huang ; Shieh, Dar-Bin
Author_Institution :
Inst. of Basic Med. Sci., Nat. Cheng Kung Univ., Tainan
Abstract :
Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor cells ongoing apoptosis. Measurement of mitochondrial membrane potential (Deltapsi) revealed a significant loss of the Deltapsi upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.
Keywords :
biomembranes; cancer; cardiovascular system; cellular biophysics; dosimetry; lipid bilayers; nanoparticles; oxidation; proteins; tumours; anticancer drug carrier; apoptosis; arthrosclerosis; auto-oxidation; cancer cell; cardiovascular diseases; chemotherapeutic agent; effective anticancer bio nanoparticle; endothelial cell apoptosis; endothelial cells; lipid metabolism; low density lipoproteins; mitochondrial membrane potential; oxidized LDL; tumor cells; Biochemistry; Biomembranes; Cancer; Cardiovascular diseases; Educational institutions; Fluorescence; Lipidomics; Loss measurement; Nanoparticles; Tumors;
Conference_Titel :
Nanotechnology, 2008. NANO '08. 8th IEEE Conference on
Conference_Location :
Arlington, TX
Print_ISBN :
978-1-4244-2103-9
Electronic_ISBN :
978-1-4244-2104-6
DOI :
10.1109/NANO.2008.203
