Analysis of Wheezes in Asthmatic Patients during Spontaneous Respiration

Respiratory sound analysis can offer important information related to pulmonary diseases. Wheezes have been reported as adventitious respiratory sounds in asthmatic or obstructive patients, during forced exhalation maneuvers. In this work, we propose a method for analysis of respiratory sounds in frequency domain, during spontaneous ventilation. Two databases were analyzed: signals acquired during spirometry (DBspir), composed by 23 subjects (N=15 asthmatics, N=8 control); and signals acquired during spontaneous ventilation for 120 seconds (DBsv), composed by 26 asthmatics. Using an autoregressive model (AR, order 16), it was calculated the Power Spectral Density (PSD) for each expiration and the peak frequency (fp) was estimated. Higher values of fp were found in asthmatic patients with severe obstruction in relation to light obstruction or control subjects. The effect of bronchodilator inhalation in asthmatic patients was studied in the database DBsv, analyzing contribution of wheezes in the bandwidth 600-2000 Hz (HFband)., Differences of number of respiratory cycles with wheezes (Dwheez index), before and after bronchodilator inhalation were evaluated. It was found a good correlation between Dwheez and FEV1% improvement (FEV1%_imp), for FEV1%_imp > 10%. This method could predict the FEV1%_imp by means of estimation of Dwheez index during spontaneous ventilation.