• DocumentCode
    2745645
  • Title

    A model of the respiratory central pattern generator

  • Author

    Amini, Behrang ; Bidani, Akhil ; Zwischenberger, Joseph B. ; Clark, John W., Jr.

  • Author_Institution
    Dept. of Neurobiol. & Anatomy, Texas Univ., Houston, TX, USA
  • Volume
    2
  • fYear
    2004
  • fDate
    1-5 Sept. 2004
  • Firstpage
    4580
  • Lastpage
    4583
  • Abstract
    We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model was designed as a network of Hodgkin-Huxley type medullary neurons under the hypothesis that synaptic and network effects predominate over ionic influences in determining the pattern of firing seen in individual neurons. After obtaining satisfactory mimicry of these patterns we validated the model to a different set of data in order to examine its robustness in the face of transient perturbations.
  • Keywords
    bioelectric phenomena; neurophysiology; physiological models; pneumodynamics; Hodgkin-Huxley type medullary neurons; mammalian respiratory central pattern generator; medullary neurons; network effects; neuron firing; respiratory central pattern generator; synaptic effects; Anatomy; Biological system modeling; Biology computing; Biomedical engineering; Computational biology; Consortia; Frequency; Lungs; Nerve fibers; Neurons;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
  • Conference_Location
    San Francisco, CA
  • Print_ISBN
    0-7803-8439-3
  • Type

    conf

  • DOI
    10.1109/IEMBS.2004.1404270
  • Filename
    1404270