Title :
Simulating leukocyte-venule interactions - a novel agent-oriented approach
Author :
Tang, J. ; Hunt, C.A. ; Mellein, J. ; Ley, K.
Author_Institution :
California Univ., San Francisco, CA, USA
Abstract :
Leukocyte recruitment into sites of inflammation involves a complex cascade of molecular interactions between the leukocyte and the endothelial cells of the inflamed venule. This report proposes a novel agent-oriented approach for simulating leukocyte-venule interactions during inflammation. We focus on modeling and simulating the initial steps of rolling, activation, and firm adhesion of neutrophils on TNF-α-treated mouse cremaster muscle venules.
Keywords :
adhesion; blood; cellular biophysics; molecular biophysics; muscle; physiological models; TNF-/spl alpha/-treated mouse cremaster muscle venules; agent-oriented approach; endothelial cells; inflammation; leukocyte-venule interactions; molecular interactions; neutrophil activation; neutrophil adhesion; neutrophil rolling; Adhesives; Biological information theory; Biological system modeling; Biomembranes; Cells (biology); Event detection; Mice; Muscles; Recruitment; White blood cells; Adhesion; Agent-Based Model; Endothelium; Inflammation; Leukocyte; Rolling; Transmigration;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1404376
