Title :
A drug delivery system for the treatment of peripheral nervous system injuries
Author :
Soumetz, F. Caneva ; Giacomini, M. ; Phillips, J.B. ; Brown, R.A. ; Ruggiero, C.
Author_Institution :
Genova Univ., Italy
Abstract :
Recent results in biomedical engineering and materials science and technology have brought about the development of novel bioactive materials by which the repair of peripheral nervous system injuries can be improved. The formation of scarring tissue, which represents a physical barrier to axon elongation, and the not oriented outgrowth of neurites are the two major obstacles for a complete recovery of physiological nerve function. This study mainly focuses on the analysis of biocompatible constructs for the controlled release of anti-scarring antibodies by means of fluorescence spectroscopy techniques.
Keywords :
biological tissues; biomedical materials; biomedical measurement; drug delivery systems; fluorescence spectroscopy; molecular biophysics; neurophysiology; anti-scarring antibodies; axon elongation; bioactive materials; biocompatible constructs; biomedical engineering; drug delivery system; fluorescence spectroscopy; materials science; neurites; peripheral nervous system injuries; physiological nerve function; scarring tissue; Biological materials; Biomedical engineering; Biomedical materials; Drug delivery; Fluorescence; Injuries; Materials science and technology; Nerve fibers; Nervous system; Spectroscopy; Drug delivery systems; fluorescence spectroscopy; materials science and technology; materials testing; nanotechnology; nervous system; repair;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1404395
