On-line Monitoring of Penicillin Cultivation Process Based on Multi-way Partial Least Squares

On-line monitoring and fault diagnosis of a fed-batch penicillin fermentation process is presented using multi-way partial least squares method (MPLS). Since data from penicillin cultivation process are multidimensional, modeling and fault diagnosis based on the statistical data cannot be realized using traditional partial least squares (PLS) method. Multidimensional data will be cut along the variable axis, PLS model be built for every operational phase using MPLS method, and on-line monitoring and fault diagnosis of batch process be attained. The simulation is performed by means of statistical method such as Hotelling T², Q and contribution plots. From the consistency of theoretical analysis and simulation results, the implementation of the methodology is illustrated