Biocompatibility studies of materials used for chronically implantable microelectrodes

The use of biocompatible materials is important in determining the longevity of chronically implantable microelectrodes. Protein adsorption is the initial event that takes place once an implant is in the body. These adsorbed proteins are then a significant influence on the subsequent adsorption of further proteins and cells; they thus dictate the interfacial reactions and ultimately the biocompatibility of the material. Results from protein adsorption studies on materials for sensing electrodes using ellipsometry are presented. The results suggest that among the materials investigated, indium tin oxide (ITO) is the best material in preventing protein adsorption, a characteristic required for electrode recording sites