A light-regulated bio-micro-actuator powered by transgenic Drosophila melanogaster muscle tissue

Author

Suzumura, K. ; Funakoshi, K. ; Hoshino, T. ; Tsujimura, H. ; Iwabuchi, K. ; Akiyama, Y. ; Morishima, K.

Author_Institution

Tokyo Univ. of Agric. & Technol., Tokyo, Japan

fYear

2011

fDate

23-27 Jan. 2011

Firstpage

149

Lastpage

152

Abstract

This paper reports the first demonstration of a light-regulated bio-micro-actuator powered by a transgenic Drosophila melanogaster DV tissue (insect heart muscle). We expressed a mutant form of blue light-sensitive cation channel, channelrhodopsin-2, into the cell membrane of the DV tissue. The DV tissue was assembled into a micro-structure made of poly-dimethylsiloxane (PDMS). The light-sensitive DV tissue contracted synchronously with blue light irradiation, and the micro-actuator was driven in this way. The moving frequency of the micro-actuator increased as irradiation intensity and duration increased. These results demonstrate that the light-driven muscle-powered actuator will have various applications.

Keywords

bioMEMS; biological effects of optical radiation; biological techniques; biomembrane transport; biomolecular effects of radiation; cardiology; cellular effects of radiation; microactuators; muscle; polymers; proteins; blue light irradiation; blue light-sensitive cation channel; cell membrane; channelrhodopsin-2; insect heart muscle; irradiation duration; irradiation intensity; light-regulated biomicroactuator; polydimethylsiloxane; transgenic Drosophila melanogaster muscle tissue; Actuators; Heart; Insects; Microscopy; Muscles; Radiation effects; Synchronization;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on

Conference_Location

Cancun

ISSN

1084-6999

Print_ISBN

978-1-4244-9632-7

Type

conf

DOI

10.1109/MEMSYS.2011.5734383

Filename

5734383