Title :
A software package for next-gen bisulfite sequencing data analysis
Author :
Choi, Jeong-Hyeon ; Ryu, Dong-Sung ; Sureshchandra, Suhas ; Shi, Huidong ; Cho, Hwan-Gue
Author_Institution :
Cancer Center, Georgia Health Sci. Univ., Augusta, GA, USA
Abstract :
Bisulfite sequencing (BS-seq) is one of the most important sequencing protocols for genome-wide DNA methylation studies. However, it causes significant challenges in computation because it converts unmethylated cytosines to thymines. This paper presents a software package to address those challenges and to provide various kinds of analysis modules, from mapping to comparing multiple samples.
Keywords :
DNA; data analysis; genomics; medical computing; software packages; BS-seq; genome-wide DNA methylation studies; next-gen bisulfite sequencing data analysis; sequencing protocols; software package; thymines; unmethylated cytosines; Bioinformatics; Computational efficiency; DNA; Diseases; Genomics; Pipelines; Software packages; DNA methylation; bisulfite sequencing; next-gen sequencing;
Conference_Titel :
Bioinformatics and Biomedicine Workshops (BIBMW), 2011 IEEE International Conference on
Conference_Location :
Atlanta, GA
Print_ISBN :
978-1-4577-1612-6
DOI :
10.1109/BIBMW.2011.6112561
