An electrodynamic preconcentrator-integrated thermoelectric biosensor chip for continuous monitoring

An integrated thermoelectric biosensor chip is being proposed for continuous monitoring of biochemical process. It is composed of a preconcentrator and a thermoelectric biosensor. In the preconcentrator, the concentration of the biochemical sample is electrodynamically condensed, which results in enhancement of the sensitivity of the integrated sensor. Then, in the sensor, the preconcentrated target molecules interact with injected capture molecules and generate reaction heat. The reaction heat is detected based on thermoelectric effect with an integrated split-flow micro channel which provides self-compensation of thermal noise. In the fabricated biochip, 95.8% of the sample was concentrated to be 2.88-fold and detected with the sensitivity of 54.7V/molarity in biotin-streptavidin application.