Electrostatic switching biosensor - a novel label-free DNA detection using an electrode charging technique

Author

Hwang, Sung-Up ; Choi, Ji-Min ; Yang, Hyun-Ho ; Kim, Chang-Hoon ; Jung, Chulhee ; Park, Hyun Gyu ; Choi, Yang-Kyu ; Yoon, Jun-Bo

Author_Institution

Dept. of Electr. Eng., KAIST, Daejeon, South Korea

fYear

2011

fDate

23-27 Jan. 2011

Firstpage

857

Lastpage

860

Abstract

This paper reports a novel electrical detection of label-free DNA by use of a MEMS electrostatic micro-switch. The electrostatic micro-switch detects the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides using pull-in voltage shift in the micro-switch originated from negative charges of the oligonucleotides. A numerical simulation is analyzed to support this concept. The proposed biomolecule detection method using an electrostatic micro-switch represents a protocol for a new candidate of microactuator-type sensor.

Keywords

DNA; bioMEMS; biosensors; electric sensing devices; electrodes; electrostatic actuators; microfabrication; microsensors; microswitches; molecular biophysics; numerical analysis; MEMS electrostatic microswitch; biomolecule detection method; electrical detection; electrode charging technique; electrostatic switching biosensor; label-free DNA detection; microactuator-type sensor; numerical simulation; probe oligonucleotide immobilization; pull-in voltage shift; Biosensors; Electrodes; Electrostatics; Logic gates; Micromechanical devices; Probes; Switches;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on

Conference_Location

Cancun

ISSN

1084-6999

Print_ISBN

978-1-4244-9632-7

Type

conf

DOI

10.1109/MEMSYS.2011.5734560

Filename

5734560