Title :
Label free piezoelectric DNA sensor array by selective immobilization via electrochemical method
Author :
Kao, P. ; Allara, D. ; Tadigadapa, S.
Author_Institution :
Dept. of Electr. Eng., Pennsylvania State Univ., University Park, PA, USA
Abstract :
An 8-pixel quartz crystal resonator array with a fundamental resonance frequency of 73 MHz has been designed and fabricated. We established a protocol for selectively functionalizing the surface of resonator array via electrochemical desorption. The creation of hydrophobic and hydrophilic surface with methyl terminated and carboxylate terminated alkanethiols is characterized by Fourier transform spectroscopy (FTIR) and contact angle measurements. QCMs functionalized with hydrophobic and hydrophilic terminations show a clearly distinguishable response to ionic (buffer) solution.
Keywords :
DNA; Fourier transform spectra; biosensors; contact angle; crystal resonators; desorption; electrochemical analysis; electrochemical sensors; hydrophilicity; hydrophobicity; infrared spectra; microfabrication; molecular biophysics; sensor arrays; FTIR; Fourier transform spectroscopy; buffer solution; carboxylate terminated alkanethiols; contact angle measurements; electrochemical desorption; electrochemical method; frequency 73 MHz; hydrophilic surface; hydrophilic terminations; hydrophobic surface; hydrophobic terminations; ionic solution; label free piezoelectric DNA sensor array; methyl terminated alkanethiols; quartz crystal resonator array; resonance frequency; selective immobilization; Arrays; Biosensors; Crystals; Electrodes; Ethanol; Gold; Pixel;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-9632-7
DOI :
10.1109/MEMSYS.2011.5734571
