Title :
Synthesis of 18F-labeled probes on EWOD platform for Positron Emission Tomography (PET) preclinical imaging
Author :
Chen, S. ; Keng, P.Y. ; van Dam, R.M. ; Kim, C.-J.
Author_Institution :
Bioeng. Dept., Univ. of California, Los Angeles, Los Angeles, CA, USA
Abstract :
We demonstrate the synthesis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) on an electrowetting-on-dielectric (EWOD) platform using multifunctional electrodes (for heating, temperature sensing, and EWOD driving). A revised chemistry to incorporate advantages of microfluidic volumes is used to produce multiple doses of PET tracer for preclinical imaging. The success is confirmed by imaging mice with radiotracers produced on chip. This is an important step toward the development of an affordable, universal synthesizer for imaging tracers used in Positron Emission Tomography (PET).
Keywords :
bioMEMS; biomedical electrodes; lab-on-a-chip; microfluidics; positron emission tomography; radioactive tracers; radioisotope imaging; 2-[18F]fluoro-2-deoxy-D-glucose; 18F-labeled probe synthesis; EWOD driving; EWOD platform; PET preclinical imaging; electrowetting-on-dielectric platform; heating; imaging tracers; microfluidic volumes; multifunctional electrodes; positron emission tomography; radiotracers; temperature sensing; Electrodes; Mice; Positron emission tomography; Solvents; Water heating;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-9632-7
DOI :
10.1109/MEMSYS.2011.5734591
