Title :
A high-throughput microfluidic chip for size sorting of cells
Author :
Tan, Xuebin ; Yoon, Hyeun-Joong ; Granneman, James ; Moore, Hsiao-Ping ; Cheng, Mark Ming-Cheng
Author_Institution :
Electr. & Comput. Eng., Wayne State Univ., Detroit, MI, USA
Abstract :
We present a microfluidic cell sorter that enables high-throughput, label-free, size separation of cells (ranging from few microns to hundred microns) in heterogeneous biological samples. The separation technique we use here involves microsieves filtration and time-sequential flow rate control (back-and-forth flow) separation. The results show that our design can achieve high separation efficiency (99%) in a high-throughput manner (100~1000cells/s).
Keywords :
biological techniques; cellular biophysics; flow control; flow separation; microfiltration; microfluidics; molecular sieves; back-and-forth flow separation; cell size sorting; heterogeneous biological samples; high-throughput microfluidic chip; microsieve filtration; separation efficiency; separation technique; time-sequential flow rate control separation; Cells (biology); Force; Microfluidics; Partial discharges; Petroleum; Sorting; Valves;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-9632-7
DOI :
10.1109/MEMSYS.2011.5734615
