Title :
Joining microelectronics and microionics: Nerve cells and brain tissue on semiconductor chips
Author_Institution :
Max Planck Inst. for Biochem., Munchen
Abstract :
The direct electrical interfacing of semiconductor chips with individual nerve cells and with brain tissue is considered. At first, the structure of the cell-chip contact is described and then the electrical coupling is characterized between ion channels, the electrical elements of nerve cells, and transistors and capacitors of silicon chips. On that basis the signal transmission between microelectronics and microionics is implemented in both directions. Simple hybrid neuroelectronic systems are assembled with neuron pairs and with small neuronal networks. Finally, the interfacing with capacitors and transistors is extended to brain tissue on silicon. The application of CMOS chips with capacitively coupled recording and stimulation sites allows an imaging of neuronal activity with high spatiotemporal resolution. Goal of the work in an integration of neuronal network dynamics and digital electronics on a microscopic level for applications in brain research, medical prosthetics and information technology.
Keywords :
CMOS integrated circuits; biological tissues; biomedical electronics; brain; lab-on-a-chip; neurophysiology; CMOS chips; brain tissue; capacitively coupled recording; cell-chip contact; digital electronics; direct electrical interfacing; electrical coupling; electrical elements; hybrid neuroelectronic systems; ion channels; microelectronics; microionics; nerve cells; neuronal activity; neuronal network dynamics; semiconductor chips; signal transmission; silicon chips; spatiotemporal resolution; Assembly systems; Biological neural networks; Brain; Capacitors; Contacts; Couplings; High-resolution imaging; Microelectronics; Neurons; Silicon;
Conference_Titel :
Solid State Circuits Conference, 2007. ESSCIRC 2007. 33rd European
Conference_Location :
Munich
Print_ISBN :
978-1-4244-1125-2
DOI :
10.1109/ESSCIRC.2007.4430245