Title :
Integration of high-efficiency capture and magneto-hydrodynamic retrieval of particles on a centrifugal microfluidic platform
Author :
Burger, Robert ; Reith, Patrick ; Abgrall, Patrick ; Ducrée, Jens
Author_Institution :
Dublin City Univ., Dublin, Ireland
Abstract :
This work presents for the first time a centrifugal platform which fully integrates efficient centrifugal trapping, retention and release of particles from an array of geometrical V-cup structures through novel magneto-hydrodynamic pumping principle. This mechanical actuator represents a band pass which is inactive at the high rotational frequencies required in a first trapping and assay phase while inducing hydrodynamic pumping for recovering the trapped particles from the V-cups at low frequencies. The merely frequency-controlled operation will allow an instrumentally very simple implementation of cell-based screening and subsequent off-chip analysis.
Keywords :
magnetohydrodynamics; microactuators; microfluidics; assay phase; band pass; cell-based screening; centrifugal microfluidic platform; centrifugal trapping; frequency-controlled operation; geometrical V-cup structures; high rotational frequency; hydrodynamic pumping; magnetohydrodynamic pumping principle; mechanical actuator; particle magneto-hydrodynamic retrieval; subsequent off-chip analysis; Acoustics; Actuators; Arrays; Magnetic resonance imaging; Microfluidics; Permanent magnets; Spinning;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-9632-7
DOI :
10.1109/MEMSYS.2011.5734633