Title :
A CMOS-based Microelectrode Array for Information Processing with Natural Neurons
Author :
Hafizovic, S. ; Heer, F. ; Frey, U. ; Ugniwenko, T. ; Blau, A. ; Ziegler, C. ; Hierlemann, A.
Author_Institution :
Phys. Electron. Lab., ETH Zurich
Abstract :
We report on a complementary-metal-oxide-semiconductor-based system that is capable of bidirectionally communicating (stimulation and recording) with electrogenic cells such as neurons or cardiomyocytes. It is is targeted at investigating electrical signal propagation within cellular networks in vitro. Experiments including the stimulation of neurons with two different spatio-temporal patterns and the recording of the triggered spiking activity have been carried out. The neuronal response patterns have been successfully classified (83% correct classifications) with respect to the different stimulation patterns. It will be demonstrated that information processing using natural neuronal networks may be possible
Keywords :
CMOS integrated circuits; microelectrodes; neurophysiology; CMOS-based microelectrode array; cellular networks; complementary-metal-oxide-semiconductor-based system; electrical signal propagation; electrogenic cells; information processing; natural neurons; neuronal response patterns; CMOS technology; Cardiology; Electrodes; Information processing; Microelectrodes; Neural engineering; Neurons; Sensor arrays; Temperature sensors; Voltage;
Conference_Titel :
Neural Engineering, 2007. CNE '07. 3rd International IEEE/EMBS Conference on
Conference_Location :
Kohala Coast, HI
Print_ISBN :
1-4244-0792-3
Electronic_ISBN :
1-4244-0792-3
DOI :
10.1109/CNE.2007.369767
