Simulation of three electrode device for bioimpedance study using COMSOL Multiphysics

This paper presents the standardization of three electrode device for bioimpedance study. The COMSOL Multiphysics is used as the simulation tool for the characterization of the microdevice. In the last decades, the bioimpedance methodology has been extensively used to study the different aspects of biomedical practices. The Micro Electro Mechanical system (MEMS) helps to fabricate miniature devices for the bioimpedance study. In this work a MEMS based three electrode device is simulated using COMSOL Multiphysics to find out the impedance of Phosphate Buffered Solution (PBS) which is the physiological medium for most biological studies and used to stabilize the microelectrodes under testing. The impedance obtained from COMSOL environment is processed with an equivalent circuits simulator named as ZsimpWin by taking into account the equivalent circuit of the PBS.