A two point T1 measurement sequence for in vivo spectroscopy

The objective of the authors´ work is to provide a two point T₁ measurement technique to enable well localised spectra to be obtained within an acceptable time scale, from which the T₁ relaxation times of the chemically shifted lines in the spectrum can be calculated. The method is demonstrated by measuring the T₁´s of a set of calibrated gadolinium-doped water phantoms. In vivo T₁ values obtained by the technique for the inorganic phosphate, the nucleotide triphosphate, α, β, and γ and phosphocreatine metabolites for the calf muscle of normal volunteers are also presented