Title :
Alpha-amylase activity of tannin isolated from Terminalia chebula
Author :
Mukherjee, Sayan ; Mitra, Abhijit ; Dey, Satyahari ; Thakur, Goutam
Author_Institution :
Sch. of Med. Sci. & Technol., Indian Inst. of Technol. Kharagpur, Kharagpur, India
Abstract :
One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of 100μg/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.
Keywords :
biological techniques; biomedical materials; enzymes; molecular biophysics; patient treatment; Terminalia chebula; acarbose; alpha-amylase activity; antidiabetic agent; carbohydrate hydrolyzing enzymes; fruit alcoholic extract; porcine pancreatic amylase; potato starch; tannin; therapeutic approach; type 2 diabetes mellitus treatment; Cancer; Diabetes; Educational institutions; Materials; Stress; Tumors; acarbose; alpha-amylase enzyme; postprandial; tannins; type 2 diabetes mellitus;
Conference_Titel :
Systems in Medicine and Biology (ICSMB), 2010 International Conference on
Conference_Location :
Kharagpur
Print_ISBN :
978-1-61284-039-0
DOI :
10.1109/ICSMB.2010.5735421
