Title :
Clustering microarray data using fuzzy clustering with viewpoints
Author :
Karayianni, K.N. ; Spyrou, George M. ; Nikita, Konstantina S.
Author_Institution :
Sch. of Electr. & Comput. Eng., Nat. Tech. Univ. of Athens, Athens, Greece
Abstract :
This paper studies the application of fuzzy clustering with viewpoints in order to cluster cell samples according to their gene expression profile. This method combines fuzzy clustering with external domain knowledge represented by the so-called viewpoints. The viewpoints that we employ are obtained from previously available expression data. The method was compared to the clustering algorithms of k-means, fuzzy c-means, affinity propagation, as well as a method of clustering microarray data that is based on prior biological knowledge, and has shown comparable/improved results over them.
Keywords :
biology computing; cellular biophysics; fuzzy set theory; genetics; knowledge representation; lab-on-a-chip; pattern clustering; affinity propagation; biological knowledge; cluster cell samples; external domain knowledge representation; fuzzy c-means clustering algorithm; gene expression profile; k-means clustering algorithm; microarray data clustering; Biology; Cancer; Clustering algorithms; Clustering methods; Indexes; Labeling; Prototypes; Clustering; microarray data; prior knowledge; viewpoints;
Conference_Titel :
Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on
Conference_Location :
Larnaca
Print_ISBN :
978-1-4673-4357-2
DOI :
10.1109/BIBE.2012.6399651