Title :
192-channel CMOS neurochemical microarray
Author :
Nazari, Meisam Honarvar ; Mazhab-Jafari, Hamed ; Leng, Lian ; Guenther, Axel ; Genov, Roman
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Toronto, Toronto, ON, Canada
Abstract :
A 16×12-channel neurochemical microarray is presented. Each channel acquires bidirectional currents down to pico-amperes proportional to the concentration of a neurochemical. By combining the current-to-frequency and the single-slope analog-to-digital converter (ADC) 110dB of dynamic range is achieved. The ADC in each channel generates a 16-bit output in less than a millisecond. The microarray with flat and 3D gold electrodes and an on-chip microfluidic network is experimentally validated in in-situ recording of neurotransmitter dopamine.
Keywords :
CMOS integrated circuits; analogue-digital conversion; 3D gold electrode; CMOS neurochemical microarray; current-to-frequency converter; neurotransmitter dopamine; on-chip microfluidic network; single-slope analog-to-digital converter; Arrays; CMOS integrated circuits; Current measurement; Electric potential; Electrodes; System-on-a-chip; Three dimensional displays;
Conference_Titel :
Custom Integrated Circuits Conference (CICC), 2010 IEEE
Conference_Location :
San Jose, CA
Print_ISBN :
978-1-4244-5758-8
DOI :
10.1109/CICC.2010.5617606
