Title :
Using analogy to predict functional regions on genes
Author :
Pastor, Jon A. ; Koile, Kimberle ; Overton, G. Christian
Author_Institution :
Unisys CAIT, Paoli, PA, USA
Abstract :
Describes a system to support prediction of functional regions (features) on genes using a form of reasoning by analogy. Analogy is a powerful tool in the study of biological systems, since analogous components typically have a biological correspondence based on evolution. The authors capitalize on this correlation between biotaxonomic relatedness and similarity of genetic structure to drive their predictions. By building a classification hierarchy whose members represent classes of related genes and classifying individual genes in this hierarchy, one can both form theories about the general structural characteristics of classes of genes, and generate hypotheses about the detailed structure of individual genes
Keywords :
cellular biophysics; inference mechanisms; analogy; classification hierarchy; functional regions; genes; prediction; reasoning by analogy; Biological systems; Buildings; DNA; Ecosystems; Eyes; Genetics; Machine learning; Organisms; Proteins; Sequences;
Conference_Titel :
System Sciences, 1991. Proceedings of the Twenty-Fourth Annual Hawaii International Conference on
Conference_Location :
Kauai, HI
DOI :
10.1109/HICSS.1991.183934