• DocumentCode
    279118
  • Title

    Using analogy to predict functional regions on genes

  • Author

    Pastor, Jon A. ; Koile, Kimberle ; Overton, G. Christian

  • Author_Institution
    Unisys CAIT, Paoli, PA, USA
  • Volume
    i
  • fYear
    1991
  • fDate
    8-11 Jan 1991
  • Firstpage
    615
  • Abstract
    Describes a system to support prediction of functional regions (features) on genes using a form of reasoning by analogy. Analogy is a powerful tool in the study of biological systems, since analogous components typically have a biological correspondence based on evolution. The authors capitalize on this correlation between biotaxonomic relatedness and similarity of genetic structure to drive their predictions. By building a classification hierarchy whose members represent classes of related genes and classifying individual genes in this hierarchy, one can both form theories about the general structural characteristics of classes of genes, and generate hypotheses about the detailed structure of individual genes
  • Keywords
    cellular biophysics; inference mechanisms; analogy; classification hierarchy; functional regions; genes; prediction; reasoning by analogy; Biological systems; Buildings; DNA; Ecosystems; Eyes; Genetics; Machine learning; Organisms; Proteins; Sequences;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    System Sciences, 1991. Proceedings of the Twenty-Fourth Annual Hawaii International Conference on
  • Conference_Location
    Kauai, HI
  • Type

    conf

  • DOI
    10.1109/HICSS.1991.183934
  • Filename
    183934