Title :
Two-dimensional magnetic droplet manipulation platform for miniaturized bioanalytical applications
Author :
Lehmann, U. ; Vandevyver, C. ; Parashar, V.K. ; DeCourten, D. ; Gijs, M.A.M.
Author_Institution :
Inst. of Microelectron. & Microsystems, Lausanne
Abstract :
We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles contained within aqueous droplets. Our setup enables the easy conversion of macroscopic bioanalytical protocols into the lab-on-a-chip format. Here we present the implementation of a DNA extraction and purification protocol as well as the on-chip optical detection of bioactive molecules. In both cases the miniaturization results in a decrease of the reaction and detection time as well as an increase in sensitivity.
Keywords :
DNA; biological techniques; biosensors; lab-on-a-chip; magnetic particles; microsensors; molecular biophysics; optical sensors; DNA extraction; DNA purification; aqueous droplets; bioactive molecules; lab-on-a-chip; magnetic field interaction; magnetic microparticles; miniaturized bioanalytical applications; on-chip optical detection; two-dimensional magnetic droplet manipulation; Biomedical optical imaging; DNA; Lab-on-a-chip; Magnetic fields; Magnetic liquids; Micromagnetics; Optical detectors; Optical sensors; Protocols; Purification;
Conference_Titel :
Micro Electro Mechanical Systems, 2007. MEMS. IEEE 20th International Conference on
Conference_Location :
Hyogo
Print_ISBN :
978-1-4244-095-5
Electronic_ISBN :
1084-6999
DOI :
10.1109/MEMSYS.2007.4433119
